BCG contraindcation

من طرف karima mahmod الأحد نوفمبر 08, 2009 7:00 pm

BCG Vaccine SSI should not be administered to individuals known to be hypersensitive to any component of the vaccine.

Normally, the vaccination should be postponed in persons with pyrexia or generalised infected skin conditions. Eczema is not a contraindication, but the vaccine site should be lesion free.

BCG Vaccine SSI should not be given to persons receiving systemic corticosteroids or immunosuppressive treatment including radiotherapy, to those suffering from malignant conditions (e.g., lymphoma, leukaemia, Hodgkin’s disease or other tumours of the reticulo-endothelial system), those with primary or secondary immunodeficiencies, those with HIV-infection, including infants born to HIV-positive mothers. The reaction to BCG vaccination may be exaggerated in these patients, and a generalised BCG-infection is possible.

BCG Vaccine SSI should not be given to patients who are receiving anti-tuberculosis drugs.

4.4. Special warnings and precautions for use
Although anaphylaxis is rare, facilities for its management should always be available during vaccination. Whenever possible, patients should be observed for an allergic reaction for up to 15-20 minutes after receiving immunization.

Tuberculin positive persons (consult national recommendations for the definition of a positive tuberculin reaction) do not require the vaccine. Administration of the vaccine to such persons may result in a severe local reaction.

Injections made too deeply increase the risk of lymphadenitis and abscess formation.

Regarding undersirable effects caused by BCG-infection and the susceptibility of the strain to anti-tuberculous drugs refer to section 4.8.

4.5. Interactions with other medicinal products and other forms of interaction
Intradermal BCG vaccination may be given concurrently with inactivated or live vaccines, including combined measles, mumps and rubella vaccines.

Other vaccines to be given at the same time as BCG Vaccine SSI should not be given into the same arm. If not given at the same time an interval of not less than four weeks should normally be allowed to lapse between the administrations of any two live vaccines.

It is advisable not to give further vaccination in the arm used for BCG vaccination for 3 months because of the risk of regional lymphadenitis.

4.6. Pregnancy and lactation
Although no harmful effects to the foetus have been associated with BCG vaccine, vaccination is not recommended during pregnancy or lactation.
However, in areas with high risk of tuberculosis infection, BCG may be given during pregnancy or lactation if the benefit of vaccination outweighs the risk.

4.7. Effects on the ability to drive and use machines
BCG Vaccine SSI has no or negligible influence on the ability to drive and use machines.